Tumor regression grade combined with lymph node status in esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy.

ABSTRACT:

Introduction

We aimed to elucidate the prognostic value of tumor regression grade (TRG) combined with lymph node status compared with the 8th edition of the ypTNM staging system in patients with advanced esophageal squamous cell cancer (ESCC) after neoadjuvant chemoradiotherapy (nCRT).

Methods

We enrolled 325 patients with ESCC who underwent nCRT followed by complete resection. We adopted the modified Schneider TRG system, with high (ypT0N0), mid (ypT0N+ or ypT + N0), and low (ypT + N+). After developing a multivariable Cox model, the discrimination ability of the ypStage and TRG systems was evaluated using the Akaike Information Criterion (AIC) and R² measure.

Results

The mean duration of follow-up was 56.7 ± 43.3 months. The survival curves between the ad

SUBMITTER: Yun JK 

PROVIDER: S-EPMC9554450 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature