Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis.

ABSTRACT: Staphylococcus epidermidis is one of the most common bacteria of the human skin microbiota. Despite its role as a commensal, S. epidermidis has emerged as an opportunistic pathogen, associated with 80% of medical devices related infections. Moreover, these bacteria are extremely difficult to treat due to their ability to form biofilms and accumulate resistance to almost all classes of antimicrobials. Thus new preventive and therapeutic strategies are urgently needed. However, the molecular mechanisms associated with S. epidermidis colonisation and disease are still poorly understood. A deeper understanding of the metabolic and cellular processes associated with response to environmental factors characteristic of SE ecological niches in health and disease might provide

SUBMITTER: Goncalves LG 

PROVIDER: S-EPMC9554481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature