Obesity is associated with a higher Torque Teno viral load compared to leanness.

ABSTRACT:

Introduction

Obesity affects a rising proportion of the population and is an important risk factor for unfavorable outcomes in viral disease including severe acute respiratory syndrome coronavirus 2- associated diseases. Torque Teno virus (TTV) is a ubiquitous and apathogenic virus which reflects the immune function of its host. The aim of this study was to investigate the association between obesity and TTV load - an indirect marker of compromised viral immune response.

Methods

TTV was quantified by TTV R-GENE^® PCR in a total of 89 participants of which 30 were lean (BMI <25 kg/m²) and 59 were obese (BMI >30 kg/m²). For 38 subjects, follow-up was available after bariatric surgery.

Results

TTV load was higher in individuals with obesit

SUBMITTER: Herz CT 

PROVIDER: S-EPMC9554490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature