Gut microbiota is associated with differential metabolic characteristics: A study on a defined cohort of Africans and Chinese.

ABSTRACT:

Objective

This study intended to determine the associations between gut microbiota and glucose response in healthy individuals and analyze the connection between the gut microbiome and glucose-metabolism-related parameters.

Methods

Fecal bacterial composition and anthropometric, body composition, body fat distribution, and biochemical measures were analyzed. A 75-g oral glucose tolerance test (OGTT) was given to each participant to investigate changes in glucagon-like peptide 1 (GLP-1), insulin, and glucose. The whole body fat and the regions of interest of local body composition were analyzed using dual-energy X-ray absorptiometry (DEXA), and gut microbiota composition was assessed through variable regions (V3-V4) of the bacterial 16s ribosomal RNA gene using high-throughpu

SUBMITTER: Nizigiyimana P 

PROVIDER: S-EPMC9554505 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature