Diesel-derived PM_2.5 induces impairment of cardiac movement followed by mitochondria dysfunction in cardiomyocytes.

ABSTRACT: Particulate matter (PM) in polluted air can be exposed to the human body through inhalation, ingestion, and skin contact, accumulating in various organs throughout the body. Organ accumulation of PM is a growing health concern, particularly in the cardiovascular system. PM emissions are formed in the air by solid particles, liquid droplets, and fuel - particularly diesel - combustion. PM_2.5 (size < 2.5 μm particle) is a major risk factor for approximately 200,000 premature deaths annually caused by air pollution. This study assessed the deleterious effects of diesel-derived PM_2.5 exposure in HL-1 mouse cardiomyocyte cell lines. The PM_2.5-induced biological changes, including ultrastructure, intracellular reactive oxygen species (ROS) generation, viability,

SUBMITTER: Shin TH 

PROVIDER: S-EPMC9554599 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature