Revealing bacteria-phage interactions in human microbiome through the CRISPR-Cas immune systems.

ABSTRACT: The human gut microbiome is composed of a diverse consortium of microorganisms. Relatively little is known about the diversity of the bacteriophage population and their interactions with microbial organisms in the human microbiome. Due to the persistent rivalry between microbial organisms (hosts) and phages (invaders), genetic traces of phages are found in the hosts' CRISPR-Cas adaptive immune system. Mobile genetic elements (MGEs) found in bacteria include genetic material from phage and plasmids, often resultant from invasion events. We developed a computational pipeline (BacMGEnet), which can be used for inference and exploratory analysis of putative interactions between microbial organisms and MGEs (phages and plasmids) and their interaction network. Given a collection of genomes as th

SUBMITTER: Monshizadeh M 

PROVIDER: S-EPMC9554610 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature