Dataset Information

International consensus on radiotherapy in metastatic non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death worldwide, with non-small cell lung cancer (NSCLC) accounting for most cases. While radiotherapy has historically served as a palliative modality in metastatic NSCLC, considerable advances in its technology and the continuous development of cutting-edge therapeutic agents, such as targeted therapy and immune checkpoint inhibitors (ICIs), are increasing its role in the multi-disciplinary management of the disease.

Methods

International radiotherapy experts were convened to consider and reach consensuses on the clinical utilities of radiotherapy in metastatic NSCLC, with the aim to provide patient-focused, up to date, evidence-based, recommendations to assist cancer specialists in the management of patients with metastatic NSCLC worldwide.

Results

Timely radiotherapy can offer rapid symptom alleviation and allow subsequent aggressive treatment approaches in patients with heavy tumor burden and/or oncologic emergencies. In addition, appropriate incorporation of radiotherapy as concurrent, consolidation, or salvage therapy makes it possible to achieve long-term survival, or even cure, for patients with oligo-metastatic disease. Cranial radiotherapy plays an important role in the management of brain metastasis, potentially augmenting the response and prolonging survival associated with targeted agents and ICIs. However, key questions remain, such as the appropriate choice of radiation techniques, optimal sequence of systemic therapies and radiotherapy, and optimal patient selection for such combination strategies. Although a strong rationale for combining radiotherapy and ICIs exists, its optimal parameters in this setting remain to be established.

Conclusions

In the modern era, radiotherapy serves not only as a palliative tool in metastatic NSCLC, but also plays active roles in patients with oligo-focal disease, CNS metastasis and receiving ICIs.

SUBMITTER: Zhu Z

PROVIDER: S-EPMC9554677 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

International consensus on radiotherapy in metastatic non-small cell lung cancer.

Zhu Zhengfei Z Ni Jianjiao J Cai Xuwei X Su Shengfa S Zhuang Hongqing H Yang Zhenzhou Z Chen Ming M Ma Shenglin S Xie Conghua C Xu Yaping Y Li Jiancheng J Ge Hong H Liu Anwen A Zhao Lujun L Rao Chuangzhou C Xie Congying C Bi Nan N Hui Zhouguang Z Zhu Guangying G Yuan Zhiyong Z Wang Jun J Zhao Lina L Zhou Wei W Rim Chai Hong CH Navarro-Martin Arturo A Vanneste Ben G L BGL Ruysscher Dirk De D Choi J Isabelle JI Jassem Jacek J Chang Joe Y JY Kepka Lucyna L Käsmann Lukas L Milano Michael T MT Van Houtte Paul P Suwinski Rafal R Traverso Alberto A Doi Hiroshi H Suh Yang-Gun YG Noël Georges G Tomita Natsuo N Kowalchuk Roman O RO Sio Terence T TT Li Baosheng B Lu Bing B Fu Xiaolong X

Translational lung cancer research 20220901 9

<h4>Background</h4>Lung cancer is the leading cause of cancer-related death worldwide, with non-small cell lung cancer (NSCLC) accounting for most cases. While radiotherapy has historically served as a palliative modality in metastatic NSCLC, considerable advances in its technology and the continuous development of cutting-edge therapeutic agents, such as targeted therapy and immune checkpoint inhibitors (ICIs), are increasing its role in the multi-disciplinary management of the disease.<h4>Meth ...[more]

PMID: 36248338

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Dataset Information

International consensus on radiotherapy in metastatic non-small cell lung cancer.

Background

Methods

Results

Conclusions

Publications

International consensus on radiotherapy in metastatic non-small cell lung cancer.

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