Lung function impairment in the German Lung Cancer Screening Intervention Study (LUSI): prevalence, symptoms, and associations with lung cancer risk, tumor histology and all-cause mortality.

ABSTRACT:

Background

Lung cancer screening may provide a favorable opportunity for a spirometry examination, to diagnose participants with undiagnosed lung function impairments, or to improve targeting of computed tomography (CT) screening intensity in view of expected net benefit.

Methods

Spirometry was performed in the CT screening arm (n=2,029) of the German Lung Cancer Screening Intervention Study (LUSI)-a trial examining the effects of annual CT screening on lung cancer mortality, in 50-69-year-old long-term smokers. Participants were classified as having chronic obstructive pulmonary disease (COPD) [forced expiration in one second (FEV₁)/forced vital lung capacity (FVC) <0.7], preserved ratio impaired spirometry (PRISm; FEV₁/FVC ≥0.7 and FEV₁% pr

SUBMITTER: Kaaks R 

PROVIDER: S-EPMC9554689 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature