Changes in serum transforming growth factor-beta concentration as a predictive factor for radiation-induced lung injury onset in radiotherapy-treated patients with locally advanced lung cancer.

ABSTRACT:

Background

Radiation-induced lung injury (RILI) occurs after chest radiation therapy, which ranges from acute radiation pneumonia to subsequent radiation pulmonary fibrosis. However, they are difficult to predict. The study aimed to examine the predictive utility of serum levels of transforming growth factor-beta (TGF-β) for radiation-induced lung injury.

Methods

This single-center prospective observational study enrolled 21 patients with locally advanced lung cancer who underwent chest radiation therapy. We measured the serum levels of TGF-β, Krebs von Denlungen-6, and granulocyte colony-stimulating factor (GCSF) eight times immediately before irradiation.

Results

Seven, four, eight, and one patient had Grade 0, 1, 2, and 3 radiation-induced lung injury, respectively

SUBMITTER: Seto Y 

PROVIDER: S-EPMC9554693 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature