Pathobiological functions and clinical implications of annexin dysregulation in human cancers.

ABSTRACT: Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throughout the genome on eight different chromosomes. According to their distinct tissue distribution and subcellular localization, annexins have been functionally implicated in a variety of biological processes relevant to both physiological and pathological conditions. Dysregulation of annexin expression patterns and functions has been revealed as a common feature in multiple cancers, thereby emerging as potential biomarkers and molecular targets for clinical application. Nevertheless, translation o

SUBMITTER: Prieto-Fernandez L 

PROVIDER: S-EPMC9554710 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature