Polymorphisms of pharmacogenetic candidate genes affect etomidate anesthesia susceptibility.

ABSTRACT: Purpose: Etomidate is widely used in general anesthesia and sedation, and significant individual differences are observed during anesthesia induction. This study aimed to explore the molecular mechanisms of different etomidate susceptibility at the genetic level. Methods: 128 patients were enrolled in the study. The bispectral index (BIS), mean arterial pressure (MAP) and heart rate (HR) were recorded when the patients entered the operating room for 5 min, before the administration of etomidate, 30 s, 60 s, 90 s, 120 s and 150 s after the administration of etomidate, and the corresponding single nucleotide polymorphisms (SNPs) were analyzed. Results: Significant individual differences were observed in etomidate anesthesia. The results of two-way ANOVA showed that CYP2C

SUBMITTER: Ma L 

PROVIDER: S-EPMC9554742 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature