Replacing performance status with a simple patient-reported outcome in palliative radiotherapy prognostic modelling.

ABSTRACT:

Background and purpose

Prognostication is key to determining care in advanced incurable cancer. Although performance status (PS) has been shown to be a strong prognostic predictor, inter-rater reliability is limited, restricting models to specialist settings. This study assessed the extent to which a simple patient-reported outcome measure (PROM), the EQ-5D, may replace PS for prognosis of patients with bone metastases.

Materials and methods

Data from 1,011 patients in the Dutch Bone Metastasis Study were used. Cox proportional hazards models were developed to investigate the prognostic value of models incorporating PS alone, the EQ-5D SC dimension alone, all EQ-5D dimensions and EQ-VAS, and finally all dimensions and PS. Three prognostic groups were identified and performan

SUBMITTER: Howdon D 

PROVIDER: S-EPMC9554755 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature