Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.

ABSTRACT:

Rationale & objective

Cardiovascular disease (CVD) is a major cause of mortality among people with diabetic kidney disease (DKD). The pathophysiology is inadequately explained by traditional CVD risk factors. The uremic solutes trimethylamine-N-oxide (TMAO) and asymmetric and symmetric dimethylarginine (ADMA, SDMA) have been linked to CVD in kidney failure with replacement therapy (KFRT), but data are limited in populations with diabetes and less severe kidney disease.

Study design

Observational cohort.

Settings & participants

Random subcohort of 555 REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants with diabetes and estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² at study entry.

Exposure

ADMA, SDMA,

SUBMITTER: Sapa H 

PROVIDER: S-EPMC9554797 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature