Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project.

ABSTRACT: Pharmacogenetic testing is increasingly provided by clinical and research laboratories; however, only a limited number of quality control and reference materials are currently available for many of the TPMT and NUDT15 variants included in clinical tests. To address this need, the Division of Laboratory Systems, Centers for Disease Control and Prevention-based Genetic Testing Reference Material (GeT-RM) coordination program, in collaboration with members of the pharmacogenetic testing and research communities and the Coriell Institute for Medical Research, has characterized 19 DNA samples derived from Coriell cell lines. DNA samples were distributed to four volunteer testing laboratories for genotyping using a variety of commercially available and laboratory developed tests and/or Sanger se

SUBMITTER: Pratt VM 

PROVIDER: S-EPMC9554816 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature