Quantitative Analysis of Porous Silicon Nanoparticles Functionalization by ¹H NMR.

ABSTRACT: Porous silicon (PSi) nanoparticles have been applied in various fields, such as catalysis, imaging, and biomedical applications, because of their large specific surface area, easily modifiable surface chemistry, biocompatibility, and biodegradability. For biomedical applications, it is important to precisely control the surface modification of PSi-based materials and quantify the functionalization density, which determines the nanoparticle's behavior in the biological system. Therefore, we propose here an optimized solution to quantify the functionalization groups on PSi, based on the nuclear magnetic resonance (NMR) method by combining the hydrolysis with standard ¹H NMR experiments. We optimized the hydrolysis conditions to degrade the PSi, providing mobility to the molecules

SUBMITTER: Cheng R 

PROVIDER: S-EPMC9554871 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature