Hydrolytically Degradable PEG-Based Inverse Electron Demand Diels-Alder Click Hydrogels.

ABSTRACT: Hydrogels cross-linked by inverse electron demand Diels-Alder (iEDDA) click chemistry are increasingly used in biomedical applications. With a few exceptions in naturally derived and chemically modified macromers, iEDDA click hydrogels exhibit long-term hydrolytic stability, and no synthetic iEDDA click hydrogels can undergo accelerated and tunable hydrolytic degradation. We have previously reported a novel method for synthesizing norbornene (NB)-functionalized multiarm poly(ethylene glycol) (PEG), where carbic anhydride (CA) was used to replace 5-norbornene-2-carboxylic acid. The new PEGNB_CA-based thiol-norbornene hydrogels exhibited unexpected fast yet highly tunable hydrolytic degradation. In this contribution, we leveraged the new PEGNB_CA macromer for forming iEDD

SUBMITTER: Dimmitt NH 

PROVIDER: S-EPMC9554872 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature