Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM.

ABSTRACT: Immunogenic cell death (ICD) is a type of cell death that leads to the regulation and activation of the immune response, which is marked by the exposure and delivery of damage-associated molecular patterns (DAMPs) in the tumor microenvironment. Accumulating evidence has revealed the significance of ICD-related genes in tumor progression and therapeutic response. In this study, we obtained two ICD-related clusters for glioblastoma (GBM) by applying consensus clustering, and further constructed a risk signature on account of the prognostic ICD genes. Based on the risk signature, we found that higher risk scores were associated with worse patient prognosis. Besides, the results illustrated that ferroptosis regulators/markers were highly enriched the high-risk group, and ferroptosis were corre

SUBMITTER: Feng S 

PROVIDER: S-EPMC9554879 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature