Ontology highlight
ABSTRACT:
SUBMITTER: Black MH
PROVIDER: S-EPMC9554938 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Black Miles H MH Gradowski Marcin M Pawłowski Krzysztof K Tagliabracci Vincent S VS
Methods in enzymology 20220418
Pseudoenzymes resemble active enzymes, but lack key catalytic residues believed to be required for activity. Many pseudoenzymes appear to be inactive in conventional enzyme assays. However, an alternative explanation for their apparent lack of activity is that pseudoenzymes are being assayed for the wrong reaction. We have discovered several new protein kinase-like families which have revealed how different binding orientations of adenosine triphosphate (ATP) and active site residue migration ca ...[more]