The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility.

ABSTRACT:

Background

Bladder cancer is the most common leading cause of mortality around the world. Previous studies have indicated that genetic factors are significantly associated with bladder cancer progression-for instance, the CYP2C8 gene is involved in bladder cancer progression. However, little is known about the impact of CYP2C8 genetic polymorphisms on bladder cancer risk. We aimed to detect the association between CYP2C8 variations and bladder cancer susceptibility.

Methods

This study included 550 healthy subjects and 217 bladder cancer patients. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the correlation of CYP2C8 polymorphisms with bladder cancer risk. Multifactor dimensionality reduction (MDR) was carri

SUBMITTER: Qu W 

PROVIDER: S-EPMC9554954 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature