The synergistic effect of depression and moderate chronic kidney disease on the all-cause and cardiovascular disease mortality among adults: a retrospective cohort study.

ABSTRACT:

Background

The relationship between the coexistence of depression and moderate chronic kidney disease (CKD) and mortality is unclear. We aimed to investigate whether there is a synergistic effect of depression and moderate CKD on the all-cause and cardiovascular disease (CVD) mortality among adults.

Methods

We studied 24,412 participants from the National Health and Nutrition Examination Survey 2005-2014 with a mortality follow-up assessment in 2015. Four groups were created based on depression and CKD status: Group 1, no depression and no CKD; Group 2, depression present and no CKD; Group 3: no depression and CKD present; Group 4: depression present and CKD present. Moderate CKD was defined as an estimated glomerular filtration rate of 15-59 mL/min/1.73 m² (Stage

SUBMITTER: Meng F 

PROVIDER: S-EPMC9554995 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature