Immunotheranostic microbubbles (iMBs) - a modular platform for dendritic cell vaccine delivery applied to breast cancer immunotherapy.

ABSTRACT:

Background

Therapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen presentation and immune response has spurred interest on DC-based vaccines for anti-cancer therapy. However, despite favorable safety profiles in patients, current DC-vaccines have not yet presented significant outcome due to technical barriers in active DC delivery, tumor progression, and immune dysfunction. To maximize the therapeutic response, we present here a unique cell-free DC-based vaccine capable of lymphoid organ targeting and eliciting T-cell-mediated anti-tumor effect.

Methods

We developed this novel immunotheranostic platform using plasma membranes derived from activated DCs incorporated

SUBMITTER: Jugniot N 

PROVIDER: S-EPMC9555090 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature