Familial risk associated with lung cancer as a second primary malignancy in first-degree relatives.

ABSTRACT:

Background

Aggregation of lung cancer (LCa) in family members is well-documented. However, little is known on the familial risk of LCa when first-degree relatives (FDRs, parents or siblings) are diagnosed with LCa as a second primary malignancy (LCa-2). We aimed to investigate whether and to what extent a family history of LCa-2 was associated with an increased LCa risk.

Methods

In this Swedish national cohort we identified 127,865 individuals who had one FDR affected by LCa as a first primary cancer (LCa-1) and 15,490 individuals who had one FDR affected by LCa-2, respectively. We then estimated relative risk (RR) of LCa using those without cancer family history as reference.

Results

The number of LCa-2 has been increasing annually and rather similarly in men and wom

SUBMITTER: Ji J 

PROVIDER: S-EPMC9555112 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature