Impact of poly(ethylene glycol) functionalized lipids on ordering and fluidity of colloid supported lipid bilayers.

ABSTRACT: Colloid supported lipid bilayers (CSLBs) are highly appealing building blocks for functional colloids. In this contribution, we critically evaluate the impact on lipid ordering and CSLB fluidity of inserted additives. We focus on poly(ethylene glycol) (PEG) bearing lipids, which are commonly introduced to promote colloidal stability. We investigate whether their effect on the CSLB is related to the incorporated amount and chemical nature of the lipid anchor. To this end, CSLBs were prepared from lipids with a low or high melting temperature (T_m), DOPC, and DPPC, respectively. Samples were supplemented with either 0, 5 or 10 mol% of either a low or high T_m PEGylated lipid, DOPE-PEG₂₀₀₀ or DSPE-PEG₂₀₀₀, respectively. Lipid ordering wa

SUBMITTER: Giakoumatos EC 

PROVIDER: S-EPMC9555145 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature