Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus.

ABSTRACT: The nucleolus is the largest structure in the nucleus, and it plays roles in mediating cellular stress responses and regulating cell proliferation, as well as in ribosome biosynthesis. The nucleolus is composed of a variety of nucleolar factors that interact with each other in a complex manner to enable its function. Many viral proteins interact with nucleolar factors as well, affecting cellular morphology and function. Here, to investigate the association between mumps virus (MuV) infection and the nucleolus, we evaluated the necessity of nucleolar factors for MuV proliferation by performing a knockdown of these factors with small interfering (si)RNAs. Our results reveal that suppressing the expression of Treacle, which is required for ribosome biosynthesis, reduced the proliferative pote

SUBMITTER: Wakata A 

PROVIDER: S-EPMC9555161 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature