Central role of PD-L1 in cardioprotection resulting from P2Y₄ nucleotide receptor loss.

ABSTRACT: A better understanding of the immune function of pericardial adipose tissue is essential to adapt treatments after myocardial infarction. We showed previously that inactivation of mouse P2Y₄ nucleotide receptor induces adiponectin overexpression and protection against myocardial infarction. We investigated here the inflammatory state of pericardial adipose tissue in ischemic P2Y₄-deficient mice. We demonstrated that P2Y₄-deficient mice displayed adipocyte beiging with increased PD-L1 expression and a higher number of regulatory leukocytes in their pericardial adipose tissue after left anterior descending artery ligation, compared to wild type mice. Effectively, a higher level of anti-inflammatory M2c macrophages and regulatory T cells was observed in perica

SUBMITTER: Horckmans M 

PROVIDER: S-EPMC9555169 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature