Control of HIV-1 Replication by CD8⁺ T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection.

ABSTRACT: Although many HIV-1-specific CD8⁺ T cell epitopes have been identified and used in various HIV-1 studies, most of these epitopes were derived from HIV-1 subtypes B and C. Only 17 well-defined epitopes, none of which were protective, have been identified for subtype A/E infection. The roles of HIV-1-specific T cells have been rarely analyzed for subtype A/E infection. In this study, we identified six novel HLA-B*15:02-restricted optimal HIV-1 subtype A/E epitopes and then analyzed the presentation of these epitopes by HIV-1 subtype A/E virus-infected cells and the T cell responses to these epitopes in treatment-naive HIV-1 subtype A/E-infected HLA-B*15:02⁺ Vietnamese individuals. Responders to the PolTY9 or PolLF10 epitope had a significantly lower plasma viral load (p

SUBMITTER: Nguyen HT 

PROVIDER: S-EPMC9555181 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature