The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019.

ABSTRACT:

Purpose

The incidence of early-onset colorectal cancer (EO-CRC), which occurs in people under age 50, has been increasing annually. The aim of this study was to provide an up-to-date estimate of the global EO-CRC burden.

Methods

We used Global Burden of Disease Study data and methodologies to describe changes in the EO-CRC burden from 1990 to 2019, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs). The driving factors for cancer burden variation were further analyzed using decomposition analysis. Frontier analysis was used to visually demonstrate the potential for burden reduction in each country or region based on their development levels.

Results

The global EO-CRC incidence more than doubled, increasing from 95,737 (95% uncertain

SUBMITTER: Pan H 

PROVIDER: S-EPMC9555189 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature