External Validation of the Lupus Multivariable Outcome Score for Systemic Lupus Erythematosus Trials.

ABSTRACT:

Objective

Development of new systemic lupus erythematosus (SLE) treatments requires an effective responder index. Toward this end, we have recently developed a new Lupus Multivariable Outcome Score (LuMOS) to optimize discrimination between actively treated patients and those on placebo. We now report on external validation of LuMOS in two independent clinical trials.

Methods

Validation was performed with the Illuminate data sets that evaluated tabalumab (TB) in SLE. To accommodate laboratory results assessed on different platforms, we developed a standardized LuMOS 2.0 model that uses z score transformations of biomarker values. For validation, we calculated LuMOS 2.0 scores at week 52 for all participants. Effect size (ES), with 95% confidence intervals (CIs), compared the

SUBMITTER: Abrahamowicz M 

PROVIDER: S-EPMC9555192 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature