Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is usually mild and self-limited in children. However, a few Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections in children may progress to severe disease with respiratory distress or can result in a multisystem inflammatory syndrome (MIS-C) associated with COVID-19. The immune mechanisms for these differential clinical outcomes are largely unknown.

Methods

A prospective cohort study was performed to analyze the laboratory parameters, antibody response, immune phenotypes and cytokine profiles of 51 children with different clinical presentations of COVID-19.

Results

We found that the absolute lymphocyte counts gradually decreased with disease severity. Furthermore, SARS-CoV-2 IgG levels in the acute pha

SUBMITTER: Talarico LB 

PROVIDER: S-EPMC9555606 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature