Risk factors, ethnicity and dementia: A UK Biobank prospective cohort study of White, South Asian and Black participants.

ABSTRACT:

Background

Our knowledge of the effect of potentially modifiable risks factors on people developing dementia is mostly from European origin populations. We aimed to explore if these risk factors had similar effects in United Kingdom (UK) White, South Asian and Black UK Biobank participants recruited from 2006-2010 and followed up until 2020.

Methods

We reviewed the literature to 25.09.2020 for meta-analyses identifying potentially modifiable risk factors preceding dementia diagnosis by ≥10 years. We calculated prevalence of each identified risk factor and association with dementia for participants aged ≥55 at registration in UK Biobank. We calculated hazard ratios using Cox regression for each risk factor, stratified by ethnic group, and tested for differences using interact

SUBMITTER: Mukadam N 

PROVIDER: S-EPMC9555673 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature