Contribution of T- and B-cell intrinsic toll-like receptors to the adaptive immune response in viral infectious diseases.

ABSTRACT: Toll-like receptors (TLRs) comprise a class of highly conserved molecules that recognize pathogen-associated molecular patterns and play a vital role in host defense against multiple viral infectious diseases. Although TLRs are highly expressed on innate immune cells and play indirect roles in regulating antiviral adaptive immune responses, intrinsic expression of TLRs in adaptive immune cells, including T cells and B cells, cannot be ignored. TLRs expressed in CD4 + and CD8 + T cells play roles in enhancing TCR signal-induced T-cell activation, proliferation, function, and survival, serving as costimulatory molecules. Gene knockout of TLR signaling molecules has been shown to diminish antiviral adaptive immune responses and affect viral clearance in multiple viral infectious animal models

SUBMITTER: Zhang E 

PROVIDER: S-EPMC9555683 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature