Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy.

ABSTRACT:

Background

Acute myocarditis is an inflammatory condition that may herald the onset of dilated cardiomyopathy (DCM) or arrhythmogenic cardiomyopathy (ACM). We investigated the frequency and clinical consequences of DCM and ACM genetic variants in a population-based cohort of patients with acute myocarditis.

Methods

This was a population-based cohort of 336 consecutive patients with acute myocarditis enrolled in London and Maastricht. All participants underwent targeted DNA sequencing for well-characterized cardiomyopathy-associated genes with comparison to healthy controls (n=1053) sequenced on the same platform. Case ascertainment in England was assessed against national hospital admission data. The primary outcome was all-cause mortality.

Results

Variants that would

SUBMITTER: Lota AS 

PROVIDER: S-EPMC9555763 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature