Landscape of Human Immunodeficiency Virus Neutralization Susceptibilities Across Tissue Reservoirs.

ABSTRACT:

Background

Human immunodeficiency virus type 1 (HIV-1) sequence diversity and the presence of archived epitope muta-tions in antibody binding sites are a major obstacle for the clinical application of broadly neutralizing antibodies (bNAbs) against HIV-1. Specifically, it is unclear to what degree the viral reservoir is compartmentalized and if virus susceptibility to antibody neutralization differs across tissues.

Methods

The Last Gift cohort enrolled 7 people with HIV diagnosed with a terminal illness and collected antemortem blood and postmortem tissues across 33 anatomical compartments for near full-length env HIV genome sequencing. Using these data, we applied a Bayesian machine-learning model (Markov chain Monte Carlo-support vector machine) that uses HIV-1 envelope se

SUBMITTER: Wang C 

PROVIDER: S-EPMC9555844 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature