Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk.

ABSTRACT: Cardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the remaining are functionally impaired. Although lipid metabolism is crucial for platelet function, little is known regarding platelet metabolic changes associated with CPB-dysfunction. Our aim is to explore possible contribution of metabolic perturbations for platelet dysfunction after cardiac surgery.

Design

Prospective cohort study.

Setting

Tertiary academic cardiothoracic-surgery ICU.

Patients

Thirty-three patients submitted to elective surgical aortic valve replacement.

Interventions

Samples from patients were collected at three time po

SUBMITTER: Velho TR 

PROVIDER: S-EPMC9555905 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature