Prenatal exposure to nitrate from drinking water and the risk of preterm birth: A Danish nationwide cohort study.

ABSTRACT: Evidence is emerging that preterm birth (PTB, birth before 37 completed weeks of gestation), a risk factor for neonatal mortality and future morbidity, may be induced by maternal nitrate ( NO3- ) exposure from drinking water. The objective of this study is to assess the association between maternal exposure to nitrate and the risk of PTB in a nationwide study of liveborn singletons.

Methods

We estimated maternal nitrate exposure from household tap water for 1,055,584 births in Denmark to Danish-born parents during 1991-2015 by linkage of individual home address(es) with nitrate concentrations from a national monitoring database. Nitrate exposure during pregnancy was modeled using four categories and continuously. Logistic models adjusted for sex, birth year, birth order, urbanicity,

SUBMITTER: Coffman VR 

PROVIDER: S-EPMC9556052 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature