Epigenome-wide association of neonatal methylation and trimester-specific prenatal PM_2.5 exposure.

ABSTRACT: Exposure to particulate matter with an aerodynamic diameter smaller than 2.5 microns (PM_2.5) can affect birth outcomes through physiological pathways such as inflammation. One potential way PM_2.5 affects physiology could be through altering DNA methylation (DNAm). Considering that exposures during specific windows of gestation may have unique effects on DNAm, we hypothesized a timing-specific association between PM_2.5 exposure during pregnancy and DNAm in the neonatal epithelial-cell epigenome.

Methods

After collecting salivary samples from a cohort of 91 neonates, DNAm was assessed at over 850,000 cytosine-guanine dinucleotide (CpG) methylation sites on the epigenome using the MethylationEPIC array. Daily ambient PM_2.5 concentrations were

SUBMITTER: Parikh MN 

PROVIDER: S-EPMC9556110 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature