Identification of the Key Genes Involved in the Tumorigenesis and Prognosis of Prostate Cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is a malignant tumor in males, with a majority of the cases advancing to metastatic castration resistance. Metastasis is the leading cause of mortality in PCa. The traditional early detection and prediction approaches cannot differentiate between the different stages of PCa. Therefore, new biomarkers are necessary for early detection and clear differentiation of PCa stages to provide precise therapeutic intervention.

Methods

The objective of the study was to find significant differences in genes and combine the three GEO datasets with TCGA-PRAD datasets (DEG). Weighted gene coexpression network analysis (WGCNA) determined the gene set and PCa clinical feature correlation module utilizing the TGGA-PRAD clinical feature data. The correlation mo

SUBMITTER: Wang W 

PROVIDER: S-EPMC9556187 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature