Lactoferrin for iron-deficiency anemia in children with inflammatory bowel disease: a clinical trial.

ABSTRACT:

Background

Iron-deficiency anemia (IDA) is common in children with inflammatory bowel disease (IBD); however, oral iron supplements are commonly associated with poor compliance due to gastrointestinal side effects. We compared the effect of lactoferrin versus oral ferrous sulfate for the treatment of IDA in children with IBD.

Methods

Ninety-two IBD children with IDA were included but only 80 children completed the study and they were randomized into two groups: ferrous sulfate group (n = 40) who received ferrous sulfate 6 mg/kg/day for 3 months and lactoferrin group (n = 40) who received lactoferrin 100 mg/day for 3 months. Complete blood count, serum iron, total iron-binding capacity (TIBC), transferrin saturation (TS), serum ferritin, interleukin-6 (IL-6), and hepcidin 25

SUBMITTER: El Amrousy D 

PROVIDER: S-EPMC9556315 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature