Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation.

ABSTRACT:

Background

Based on findings in the brain stems of SIDS victims, the serotonin transporter (5-HTT) gene has been discussed to be associated with SIDS.

Methods

In the largest study to date, we investigated the promoter length (5-HTTLPR) and intron 2 VNTR polymorphisms in 274 cases and 264 controls and the Ile425Val polymorphism in 65 cases and 64 controls. Moreover, the methylation of the internal promoter region was investigated in 35 cases and 14 controls.

Results

For 5-HTTLPR, we observed a trend towards an association of allele L (58.8% vs. 53.4%) with SIDS and significant results were observed after stratifying for age, season at death, and prone position. Nevertheless, when pooling all published data, a significant association of allele L with SIDS is confirmed (

SUBMITTER: Pfisterer N 

PROVIDER: S-EPMC9556327 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature