A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children.

ABSTRACT:

Background

Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4-2.0 mg/m² capped at 2 mg. For infants, doses vary from 0.025-0.05 mg/kg or 50-80% of the mg/m² dose. However, evidence for lower doses in infants compared to older children is lacking. This study was conducted to unravel the complex pharmacokinetics of vincristine, including the effects of age, to assist optimal dosing in this population.

Methods

206 patients (0.04-33.9 years; 25 patients < 1 years), receiving vincristine, with 1297 plasma concentrations were included. Semi-mechanistic population pharmacokinetic analyses were performed using non-linear mixed effects modelling.

Results

A three-compartment model, with one saturable compart

SUBMITTER: Nijstad AL 

PROVIDER: S-EPMC9556337 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature