Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids.

ABSTRACT:

Purpose

The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance drug loading in lipid-based formulations (LBFs). However, cationic lipids are typically toxic. Here we explore the use of lipoaminoacids (LAAs) as cationic IL counterions that degrade or digest in vivo to non-toxic components.

Methods

LAAs were synthesised via esterification of amino acids with fatty alcohols to produce potentially digestible cationic LAAs. The LAAs were employed to form ILs with tolfenamic acid (Tol) and the Tol ILs loaded into LBF and examined in vitro and in vivo.

Results

Cationic LAAs complexed with Tol to generate lipophilic Tol ILs with high drug loading in LBFs. As

SUBMITTER: Lai A 

PROVIDER: S-EPMC9556374 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature