Temperature and Heat Transfer Control During Freeze Drying. Effect of Vial Holders and Influence of Pressure.

ABSTRACT:

Objective

A common issue of freeze drying is the inhomogeneity between samples, both in regards to water content and structure. The purpose of this study is to address this issue, and try to understand the cause of inhomogeneity in the heat transfer and sample temperature.

Methods

The temperature and the heat transfer was measured using different setups, both with and without vial holders at various positions at different shelf temperature and chamber pressures. By comparing sublimation rate measurements (water sample) with temperature equilibrium measurements with a non-evaporating liquid (oil sample), the heat transfer contribution from radiation and conduction could be separated and investigated individually.

Results

The oil sample temperature increases each time t

SUBMITTER: Palmkron SB 

PROVIDER: S-EPMC9556401 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature