An allergenic plant calmodulin from Artemisia pollen primes human DCs leads to Th2 polarization.

ABSTRACT: Artemisia pollen is the major cause of seasonal allergic respiratory diseases in the northern hemisphere. About 28.57% of Artemisia allergic patients' IgE can recognize ArtCaM, a novel allergenic calmodulin from Artemisia identified in this study. These patients exhibited stronger allergic reactions and a longer duration of allergic symptoms. However, the signaling mechanism that triggers these allergic reactions is not fully understood. In this study, we found that extracellular ArtCaM directly induces the maturation of human dendritic cells (DCs), which is attributed to a series of Ca²⁺ relevant cascades, including Ca²⁺/NFAT/CaMKs. ArtCaM alone induces inflammatory response toward Th1, Th17, and Treg. Interestingly, a combination of ArtCaM and a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9556433 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature