A novel ferroptosis-related gene signature to predict overall survival in patients with osteosarcoma.

ABSTRACT:

Objectives

Ferroptosis plays vital roles in the pathogenesis of various malignant tumors. However, knowledge on roles of ferroptosis in osteosarcoma remains scarce. In the present study, a comprehensive bioinformatics analysis was performed aiming to identify ferroptosis-related genes (FRGs), construct a FRGs-based model predicting overall survival (OS), and assess the impact of these FRGs on the migration and invasion of osteosarcoma cells.

Methods

Initially, data regarding differentially expressed FRGs were obtained from the GSE160881 dataset. Prognostic significance and possible biological functions of these differentially expressed FRGs were comprehensively and systematically explored adopting a series of bioinformatics methods. The impact of cystathionine β-synthase (CB

SUBMITTER: Li J 

PROVIDER: S-EPMC9556449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature