Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.

ABSTRACT:

Background

Gastric cancer is the third leading cause of cancer-related mortality worldwide, and the 5-year survival rate remains poor, globally. Overexpression of Aldolase A (ALDOA) has been linked to tumor cell proliferation and metastasis in numerous cancer types, including pancreatic, colorectal, hepatocellular carcinoma, and lung cancer. Although the significance of ALDOA as a potential biomarker in GC prognosis has been reported, its potential role and possible mechanism of ALDOA in GC cell sensitivity to chemotherapy remains to be elucidated.

Methods

The GEPIA platform and clinical samples were used to investigate ALDOA expression in GC tumors and neighboring normal tissues. The CCK8 and colony formation tests were used to examine whether ALDOA increased GC cell prolif

SUBMITTER: Gu M 

PROVIDER: S-EPMC9556458 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature