Association of ATRX mutations with immunologically active characteristics in patients with MSI-prone tumors.

ABSTRACT:

Objectives

The role of DNA damage repair deficiency in improving immune checkpoint inhibitors (ICIs) efficacy has been widely recognized. Studies have confirmed the association of gene mutations in homologous recombination (HR) with an immune-activated microenvironment. Given the crucial role of the tumor microenvironment in ICIs response, our study aimed to identify specific HR gene mutations that influence the tumor microenvironment and thus serve as potential biomarkers for ICIs in tumors that are prone to occur with microsatellite instability (MSI) events (MSI-prone tumors).

Methods

The multi-omics and clinical data of MSI-prone tumors were extracted from ICIs-treated and non-ICIs-treated cohorts. We depicted the mutation landscape of HR genes in MSI-prone tumors and ide

SUBMITTER: Ge Y 

PROVIDER: S-EPMC9556479 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature