Serum microRNAs as non-invasive diagnostic biomarkers for intrahepatic cholestasis of pregnancy.

ABSTRACT:

Objectives

Intrahepatic cholestasis of pregnancy (IHCP) causes itching, preterm birth, and stillbirth. However, there is no accurate diagnostic method for IHCP. Currently, circulating microRNAs (miRNAs) have become candidate biomarkers for the diagnosis of multiple diseases. Here, we investigated the diagnostic value of miRNAs in IHCP and aimed to predict the molecular mechanism of IHCP pathogenesis.

Methods

We analyzed differentially expressed miRNAs in both women with IHCP and normal pregnant women. The selected candidate miRNAs were validated in 46 IHCP cases and 46 normal pregnant subjects, and we constructed receiver operator characteristic curves of miRNAs. Pearson correlations between levels of total bile acid (TBA) and differentially expressed miRNAs were also calcul

SUBMITTER: Zu Y 

PROVIDER: S-EPMC9556493 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature