Analyzing the drivers of cancer relapse: hypocalcemia and iron absorption in hormone-dependent female cancers.

ABSTRACT:

Background

Alterations in the levels of nutrients like calcium, ferritin, and electrolytes play a pivotal role in human physiology and might serve as biomarkers. Ferritin, an iron storage protein is important in various metabolic reactions of both cancer and cancer stem cells (CSCs) and is found to regulate 'stemness' leading to cancer relapse. Interestingly, ferritin levels are found to be regulated by calcium uptake. Several studies have shown that high levels of calcium inhibit absorption of iron, thereby reducing ferritin levels. In the present study, we evaluated and correlated the serum ferritin and calcium levels in pre- and post-treated hormone-dependent female cancers and deciphered their role in tumor recurrence and relapse.

Materials and methods

The present retros

SUBMITTER: Chittineedi P 

PROVIDER: S-EPMC9556499 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature