The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation.

ABSTRACT:

Introduction

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that affects approximately 1-2% of the general population. The mechanism of AF pathogenesis remains unclear. Epicardial adipose tissue (EAT), a metabolically active visceral fat depot surrounding the heart, has been shown to be closely related to AF. EAT has a biological impact on neighboring myocardium by producing a myriad of bioactive molecules, including exosomes carrying circular RNAs (circRNAs). As a new category of noncoding RNAs, circRNAs can work as efficient sponges for specific microRNAs and efficiently regulate gene expression.

Material and methods

To investigate the regulatory mechanism of circRNAs of EAT in patients with AF, we collected EAT from AF (n=6) patients and non-AF (n=6) co

SUBMITTER: Zheng H 

PROVIDER: S-EPMC9556507 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature