The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis.

ABSTRACT: Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosis states, could foster the understanding of basic disease mechanisms mediating susceptibility to psychosis, and thereby inform preventive interventions. We systematically investigated the relationship between VisDys and core clinical measures across three early phase psychiatric conditions. Second, we used a novel multivariate pattern analysis approach to predict VisDys by resting-state functional connectivity within relevant brain systems. VisDys assessed with the Schizophrenia Proneness Instrument (SPI-A), clinical measures, and resting-state fMRI data were examined in recent-onset

SUBMITTER: Schwarzer JM 

PROVIDER: S-EPMC9556592 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature